ea0025p166 | Diabetes, metabolism and cardiovascular | SFEBES2011
Lavery Gareth
, Rabbitt Elizabeth
, Zielinszka Agnieszka
, Huges Beverley
, Semjonous Nina
, Saqib Khalid
, Morgan Stuart
, Gathercole Laura
, Walker Elizabeth
, Stewart Paul
In humans glucocorticoid (GC) excess can promote hepatic glucose and triglyceride production contributing to obesity, fatty liver and diabetes. 11β-HSD1 activates GCs (11-DHC to corticosterone in mice), thereby increasing tissue concentrations. The liver has the highest 11β-HSD1 activity, and its inhibition has emerged as a therapeutic option. To investigate this we generated 11β-HSD1 liver-specific knockouts (HSD1LKO) and examined GC metabolism and responses to...